Edition 70 - October 2018 / Editorial

Editorial – Ed. 70

For this 70th edition Subject Review Section of Endopedonline we have selected to comment on a recent publication by Rhonda D. Kineman et al. (Journal of Molecular Endocrinology (61:T187-T198, 2018), which summarizes “40 years of IGF1″. focused on understanding the tissue-specific roles of the IGF1-IGF1R complex in the regulation of metabolism.Although IGF1 and its receptor do not reproduce the characteristic functions of the “hormone / specific receptor” binomials, they nevertheless share them (role of circulating IGF1, synthesized mainly in the liver), and also exceed them (specific actions in multiple tissues). Several aspects are discussed: participation in body growth, regulation of somatotrophic function, modulation of hormonal stimuli, effects on beta cells of the pancreas, production of thyroid hormones, function of ovarian granulosa cells, as well as adrenal and testicular Leydig cells. Likewise, IGF1 and its receptor act on adipose tissue, complementing their effects with insulin. For the Bibliographic Revisions Section we have selected six recent publications (see bibliographic citations in the respective Section). 1) Mosaicism 45, X / 46, XY Presenting Unilateral Cryptorchidism Isolated and a Normal Kariotype in Blood. Grazia Morandi et al., 2) Hypogonadotrophic Hypogonadism Due to a New Mutation of the FGFR1 Gene. Akkuş G et al., 3) Discordance in the Dependence on Kisspeptin Signaling in Mini Puberty vs Adolescent Puberty: Human Genetic Evidence. Shahab M et al., 4) Recurrent Copy Number Variants Associated with Syndromic Short Stature of Unknown Cause. Homma TK et al., 5) GH Therapy in Childhood Cancer Survivors: A Systematic Review and Meta-Analysis. Tamhane S et al., 6) Adreno-corticotropic Hormone (ACTH) Responses Require (in Addition to its Receptor, MC2) Actions of the Melanocortin-2 Receptor Accessory Protein (MRAP) on the Extracellular Surface of the Plasma Membrane. Malik S. et al.
For the Images in Pediatric Endocrinology Section we are showing photographs of swelling feet and hands secondary to congenital lymphedema, in a 2.5 year old girl with Turner syndrome.


Dra. Alicia Belgorosky                                                             Dr. Marco A. Rivarola

Posted in Edition 70 - October 2018, Editorial
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